GENERAL MEDICAL SCIENCES (ONCOLOGY)

SHUYING SUN, PhD Assistant Professor General Medical Sciences (Oncology) Phone: 216/368-4699 Fax: 216/368-4880 email: shuying.sun@case.edu

Research Interests

Deep sequencing data analysis
Microarray data analysis (DNA methylation and gene expression)
Statistical genetics (haplotype inference and haplotype analysis, case control association studies)
Bayesian methods, Markov Chain Monte Carlo algorithms, and linear models

Sequencing Data Interest Group (SDIG)

Recent Publications

Sun S, Greenwood CM, Neal RM. (2007) Haplotype inference using a Bayesian Hidden Markov Model. Genetic Epidemiology; 31 (8):937-948.

Clendenning M, Baze ME, Sun S, Walsh K, Liyanarachchi S, Fix D, Schumemann V, Comeras I, Deacon M, Wenstrup RJ, Thibodeau ST, Lynch HT, Hampel H, de la Chapelle A (2008). Origins and Prevalence of the American Founder Mutation of MSH2. Cancer Research; 68 (7):2145-2153.

Clendenning M, Senter L, Hampel H, Robinson K L, Sun S, Buchanan D, Walsh MD, Nilbert M, Green JS, Potter J, Lindblom A, de la Chapelle A (2008) A frame-shift mutation of PMS2 is a widespread cause of Lynch syndrome. Journal of Medical Genetics; 45: 340-345.

Lin HL, Zuo T, Lin C, Kuo CT, Liyanarachchi S, Sun S, Shen R, Deatherage DE, Potter D, Asamoto L, Lin S, Yan P, Cheng A, Ostrowski M, Huang TH (2008). Breast cancer-associated fibroblasts confer AKT1-mediated epigenetic silencing of cystatin M in epithelial cells. Cancer Research; 68:10257-10266.

Sun S, Potter D, Yan P, Huang T, and Lin S. (2008) A quantile approach to analyzing differential methylation hybridization (DMH) microarrays. Poster proceedings of the 4th International Symposium on Bioinformatics Research and Applications (ISBRA): 87-90.

Sun S, Yan P, Huang T, Lin S. (2009). Identifying differentially methylated genes using mixed effect and generalized least square models. Submitted.