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Case Comprehensive Cancer Center Newsletter

April 9, 2012

gersonMESSAGE FROM THE DIRECTOR

Stan Gerson, MD
Director, Case CCC

Case CCC Strategic Plan

In the fall of 2012, the Cancer Center submitted a Strategic Plan 2012-2018 to the institutional leadership and gained approval for the initiatives set forth in that Plan. The Cancer Center Executive Committee will maintain a consistent strategic orientation to that laid out in the Plan, with a few changes in emphasis, that are consistent with the shifts in cancer research and in the dialogue around further deployment in cancer genomics.

SOM Priorities for the Cancer Center:

  1. Recruitment of outstanding faculty. Will continue, as outlined in the Strategic Plan.
  2. Development of an integrated clinical informatics database and storage platform for cancer investigators. Working groups are now discussing governance, IT infrastructure, data stewards, indemnification, security. This will initiate as a bilateral effort CWRU-UHCMC, but can expand to other institutions.
  3. Cancer Genomics. Support for integrated cross-institutional efforts in research and clinical sequencing of cancer patients and high risk populations, informatics and database expertise, clinical testing, clinical trials and platforms to optimize high quality genomic information; an introduction and proposal will be made to the Cancer Center institutional leaders Board of Governors by June 2012.
  4. Drug Development. The Cancer Center established the Center for Cancer Drug Development in 2011 to support investigators evaluation of lead compounds identified after drug screening. Specific needs are support for better screening assays, core use, and better access to medicinal chemistry for lead compound optimization. This needs to be linked to marker assessment technology using genomics, proteomics and imaging.
  5. Cancer disparity research effort. The Cancer Center recognizes a shortcoming in this area and wishes to partner with the Urban Health Initiative, and the CTSA, to promote research into population and disparity research. Program development will require seed funding, recruitment of an established leader, and community outreach efforts.
  6. Develop a strong training and career development for outstanding graduate students and post docs. The Cancer Center believes that we do a disservice by not emphasizing this effort and supporting it in a number of ways such as:
    • Increased support for highly motivated competitive post docs ($50,000-$80,000 research supplement for 2 or 3 years for highly qualified candidates, prior to a faculty recruitment package) and outstanding junior faculty. The Cancer Center proposes that a wise investment in augmented career development packages for outstanding candidates will improve our pool of postdocs and junior faculty.
    • Improved training and career development including small start up packages for early successes in career development awards.

CASE CCC IN THE NEWS

Video: Cancer Risk Following a False-Positive Mammogram?
ABC News - Apr 5, 2012
Dr. Donna Plecha says a false-positive mammogram doesn't increase cancer risk.

Support for Dose Titration of Axitinib in AXIS Trial Results
OncLive - Apr 5, 2012
... presented at the ASCO 2012 Genitourinary Cancers Symposium by lead author Brian I. Rini, MD, associate professor of Medicine at the Cleveland Clinic ...

Researchers Present New Findings for Glioblastoma at American Association for Cancer Research
Medical Xpress - Apr 4, 2012
"The breadth and depth of this innovative cancer research presented at AACR is truly outstanding," says Stan Gerson, MD, Director of the Seidman Cancer ...A study led by Jill Barnholtz-Sloan, PhD, Associate Professor at Case Comprehensive Cancer Center ...physicians to tailor individualized treatments for specific brain cancer patients," said Andrew Sloan, MD, Co-Investigator on the study ...and Dr. Mark Chance, Vice Dean for Research and Director of the Proteomics and Bioinformatics Center...


MARK YOUR CALENDARS

Cancer Center Seminar Series: The Role of Chinese Herbal Medicine as a Modulator of Chemotherapy in the Treatment of Metastatic Colorectal Cancer: Where East Meets West
Dr. Chu

Friday, April 13
12 pm
BRB 105

Please join us April 13 for the next Cancer Center Seminar Series where Dr. Edward Chu, Chief of the Division of Hematology/Oncology and Deputy Director of the University of Pittsburgh Cancer Institute, will present The Role of Chinese Herbal Medicine as a Modulator of Chemotherapy in the Treatment of Metastatic Colorectal Cancer: Where East Meets West.

Over the past 25 years, Dr. Chu has been actively involved in basic, clinical and translational cancer research. He has a broad background in cancer pharmacology, cancer drug development, and clinical investigations. His main research efforts have focused on the design and development of novel agents and treatment approaches for the treatment of colorectal cancer and other gastrointestinal (GI) cancers, in addition to early Phase I and II clinical development of novel small molecules for non-GI cancers and other solid tumors. Over the past 7-8 years, he has developed a special interest in the development of Chinese herbal medicine as a novel approach to cancer treatment, and he and his colleagues have been investigating an interesting formulation called PHY906, which is the subject of his seminar.

Case GI SPORE Retreat

The Case Gastrointestinal Cancers SPORE Retreat will be held Friday, May 4 in Dively Hall on Case campus. Topics will include colon cancer, Barrett's Esophagus, cancer metastasis and prevention and cancer in minorities. Faculty, fellows and students in the Cancer Center community are encouraged to attend and learn more about exciting findings from researchers in the specialized program of research excellence.

The retreat will also feature a lunchtime poster session that starts at 12 pm. Postdoc, graduate and clinical fellows are encouraged to submit poster abstracts. Send poster abstracts to John Wang, PhD by April 16. A cash prize will be awarded for best poster.

Advance registration is required. Contact John Pounardjian with any questions.


ANNOUNCEMENTS

Race for the Place

The Race for the Place, an event that benefits the Gathering Place, will be held Sunday, June 3 at Beachwood Place Mall. The Case CCC is putting together a "trainee team" for the Race but would like to judge interest before officially registering the team. Any fellow or trainee who is interested in participating should contact Lyn Haselton, Case CCC Training Program Manager, at 216.844.5375 or lyn.haselton@case.edu.


NCI CANCER BULLETIN

News
Featured Article: Targeted Drug Shows Promise in Common Form of Lymphoma

Drawbacks of Adding MRI to Mammography Plus Ultrasound May Outweigh Benefits

Ultrasound-Guided Breast-Conserving Surgery May Reduce Need for Further Surgeries

Anal HPV Infections and Precancerous Lesions Are Common in Men Who Have Sex with Men

Olaparib Delays Progression of Ovarian Cancer after Initial Treatment

Transplant Recipients at Higher Risk of Aggressive Form of Lymphoma

Some Melanoma Cells May Use the Body's Immune Response to Escape Destruction

Also in the Journals: Methylation Levels in HPV DNA May Indicate Risk for Cervical Precancer

Commentary
A Conversation with Dr. Bert Vogelstein about Whole-Genome Sequencing to Predict Cancer Risk

In Depth
U.S. Cancer Deaths Continue Steady Decline

Drugs Target Epigenetic Changes to Reprogram Cancer Cells

Featured Clinical Trial: Virus Therapy for Extensive-Stage Small Cell Lung Cancer

Updates
Legislative Update

FDA Update

Notes

EVENTS

calendar

**All events are open to anyone interested in attending

April 9

Division of Gastroenterology and Liver Disease Seminar
Anil Mishra, PhD
Associate Professor, Pediatrics
University of Cincinnati
Topic: A Critical Role of Interleukin (IL)-15 and Invariant Natural Killer (iNK) T Cells in the Pathogenesis of Eosinophilic Esophagitis (EoE)
12 pm BRB 532

Pathology Research Seminar Series
Kevin Roth, MD, PhD
Professor and Chair, Neurobiology
University of Alabama at Birmingham
Topic: Lysosomotropic Therapy for Malignant Glial Neoplasm
12 pm WRB 1-413

Sequencing Data Interest Group (SDIG) Meeting
Yaomin Xu, PhD
Assistant Staff, Quantitative Health Sciences
Cleveland Clinic
Topic: Reproducible Analysis on NGS Epigenomic Data
2:30 pm WRB 1-402


April 10

Immunology Seminar Series
Fidel Zavala, MD
Professor, Molecular Microbiology and Immunology
Johns Hopkins University
Topic: Induction of Protective Memory CD8+ T Cells Against Malaria Parasites
12 pm WRB 1-413


April 11

Hematology and Oncology Division Research Conference
Lili Liu, PhD
Assistant Professor, Medicine-Hem/Onc
CWRU/UH
Topic: First Human Trial of BER Inhibitor in CLL
8 am Lerner Tower B-151

Immunology Students/Fellows Research in Progress Seminar Series
Robert Aguilar
Graduate Student, Tuohy Lab, Immunology
CWRU/Cleveland Clinic
Topic: Development of a Testicular Cancer Vaccine
AND
Anupurna Kaul
Graduate Student, Baldwin Lab, Immunology
CWRU/Cleveland Clinic
Topic: Role of CD4 T cells in Cardiac Allograft Vasculopathy
12 pm NC1-202 Cleveland Clinic

Frontiers in Molecular Medicine Symposium Series
Ann Skalka, PhD
Scientific Director, Institute for Cancer Research
WW Smith Chair in Cancer Research
Fox Chase Cancer Center
Topic: New Insights into the Structure and Function of Retroviral Integrases
4 pm WRB 1-413

Cell Death Regulation Program Meeting
Anthony Berdis, PhD
Assistant Professor, Pharmacology
CWRU
Topic DNA Damage and Repair
4:30-6 pm College Club (**please note time change)


April 12

Molecular Biology and Microbiology Seminar
Stephen Buratowski, PhD
Professor, Biological Chemistry and Pharmacology
Harvard University
Topic: Modulating Yeast Gene Expression Via Chromatin and Non-Coding Transcription
1 pm SOM W203

Case CCC Scientific Series: Stem Cells
Alex Huang, MD
Topic: Longitudinal tracking of in vivo tumor microenvironment in high definition
Jeongwu Lee, PhD
Topic: C-MET signaling in GBM stem cells and treatment resistance
Ofer Reizes, PhD
Topic: Obesity tips the scales on breast cancer: a role for the fat hormone leptin in cancer stem cells
Reception and presentations, 4-6 pm BRB 105


April 13

Taussig Cancer Institute Grand Rounds canceled

Hematology/Oncology Fellows
Ashley Rosko, MD
Fellow, Div. of Hem/Onc
CWRU/UH
Topic: TBD
8 am Wearn 137

Cancer Center Seminar Series
Edward Chu, MD
Chief, Division of Hematology/Oncology
Deputy Director, University of Pittsburgh Cancer Institute
Topic: The Role of Chinese Herbal Medicine as a Modulator of Chemotherapy in the Treatment of Metastatic Colorectal Cancer: Where East Meets West
12 pm BRB 105

Cancer Center Research in Progress Seminar
Lili Liu, MD, PhD
Associate Professor, Medicine-Hem/Onc
CWRU/UH
Topic: First in Human Trial of BER Inhibitor in CLL: Introduction of BER-targeted Therapy
4 pm WRB 3-136

 

 

Case CCC Calendar

LRI Calendar


UPCOMING CANCER CENTER SYMPOSIUMS & EVENTS

Case GI Cancers SPORE Retreat
May 4 Dively Building
Details and Agenda
Registration

Breast Cancer 2012: Risk Assessment through Survivorship
May 18
Brochure
Registration

Case CCC Scientific Series: Imaging Research
May 31
Jim Basilion, PhD
Topic: Introduction
Chris Flask, PhD
Topic: Development of PARACEST-MRI Imaging Agents for In Vivo Assessment of Autophagy OR Magnetic Resonance Imaging as an Early-Stage Biomarker
Cheryl Thompson, PhD
Topic: Variation in Breast Tissue Gene Expression by Mammographic Density
Reception and presentations, 4-6 pm WRB 1-413

Ca-PRI Annual Meeting: Learning from Our Differences
June 5-7 InterContinental Hotel
Details

ADDITIONAL UPCOMING SEMINARS & EVENTS

Department of Biomedical Engineering Special Seminar
May 3
Steve Zullo, PhD
Program Director, Division of Discovery Science and Technology
National Institute of Biomedical Imaging and Bioengineering, NIH
Topic: NIH Grant Machine Revealed, Not a Black Box Anymore
12 pm Wickenden 509


PREVIOUSLY ANNOUNCED FUNDING OPPORTUNITIES

Specialized Program of Research Excellence in Gastrointestinal Malignancies (GI SPORE)
Deadline Extended: April 13

DOD Ovarian Cancer Research Program Pilot Award
Pre-Application Deadline: April 9
Application Deadline: July 18

SU2C-CRI Cancer Immunology Translational Research Dream Team
LOI Deadline: April 9

DOD Peer Reviewed Medical Research Program Investigator-Initiated Research Award
Pre-Application Deadline: April 10
Application Deadline: July 31

DOD Ovarian Cancer Research Program Ovarian Cancer Academy Award
Pre-Application Deadline: April 17
Application Deadline: July 18

DOD Ovarian Cancer Research Program Synergistic Translational Leverage Award
Pre-Application Deadline: April 17
Application Deadline: July 18

DOD Ovarian Cancer Research Program Teal Innovator Award
Pre-Application Deadline: April 17
Application Deadline: July 18

DOD Prostate Cancer Research Program Idea Development Award
Pre-Application Deadline: April 24
Application Deadline: August 9

DOD Breast Cancer Research Program Idea Award Award
Pre-Application Deadline: April 26
Application Deadline: August 15

American Nurses Foundation Nursing Research Grants
Deadline: May 1

Howard Hughes Medical Institute Investigator Program
Deadline to establish eligibility: May 1
Application Deadline: June 13

DOD Breast Cancer Research Program Impact Award
Pre-Application Deadline: May 3
Application Deadline: August 15

DOD Breast Cancer Research Program Innovator Award Award Award
Pre-Application Deadline: May 3
Application Deadline: August 2

DOD Breast Cancer Research Program Clinical Translational Research Award
Pre-Application Deadline: May 3
Application Deadline: August 15

DOD Breast Cancer Research Program Transformative Vision Award
Pre-Application Deadline: May 3
Application: August 15

DOD Prostate Cancer Research Program Biomarker Development Award
Pre-Application Deadline: May 3
Application Deadline: August 23

DOD Prostate Cancer Research Program Clinical Exploration Award
Pre-Application Deadline: May 3
Application Deadline: August 23

DOD Prostate Cancer Research Program Laboratory - Clinical Transition Award
Pre-Application Deadline: May 3
Application Deadline: August 23

DOD Prostate Cancer Research Program Transformative Impact Award
Pre-Application Deadline: May 3
Application Deadline: August 23

DOD Prostate Cancer Research Program Synergistic Idea Development Award
Pre-Application Deadline: May 3
Application Deadline: August 9

Barrett's Esophagus Translational Research Network (BETRNet) pilot projects
Deadline: May 18

Doctors Cancer Foundation, Inc.
Deadline: May 31

DOD Prostate Cancer Research Program Exploration - Hypothesis Development Award
Pre-Application Deadline: June 6
Application Deadline: June 20

DOD Prostate Cancer Research Program Physician Research Training Award
Pre-Application Deadline: June 6
Application Deadline: June 20

DOD Prostate Cancer Research Program Postdoctoral Training Award
Pre-Application Deadline: June 6
Application Deadline: June 20

DOD Prostate Cancer Research Program Health Disparity Research Award
Pre-Application Deadline: July 26
Application Deadline: August 9

Translational Technology Concept Studies of Circulating Tumor and Endothelial Cells (CTC/CEC)
Deadline: Open

AACR Scholar-in-Training Awards - Other Conferences and Meetings
Deadline: Open

Case CCC Protocol Specific Research Support (PSRS)
Deadline: Open

International Union Against Cancer (UICC) International Cancer Technology Transfer Fellowships
Application Deadline: Open

International Waldenstrom's Macroglobulinemia Foundation (IWMF) Research Grant Program
Application Deadline: Open

SAIC-Frederick Support of the Cancer Genome Atlas Program
Application Deadline: Open

Solving Kids' Cancer Therapeutic Development Initiative
Application Deadline: Open

NCI Short-Term Scientist Exchange Program
Application Deadline: Open


NIH BULLETIN – Notices and Funding Opportunities

U.S.-China Program for Biomedical Collaborative Research (R01)(RFA-AI-12-021)

Research Supplements to Promote Diversity in Health-Related Research (Admin Supp)(PA-12-149)

Research Supplements to Promote Re-Entry into Biomedical and Behavioral Research Careers (Admin Supp)(PA-12-150)

Cancer Target Discovery and Development (CTDD) Network (U01)(CA-12-006)

Identifying Non-coding RNA Targets for Cancer Early Detection and Prevention (R21)(PA-09-200)

Produced by:
Gillian Irwin Todd
11100 Euclid Avenue, Wearn 149
Cleveland, Ohio 44106-5065
216-844-8317 phone
216-844-7832 fax
gillian.irwin@case.edu

HELP US HELP YOU!

If you have a new grant, recently won an award, or have other newsworthy items, please let us know so we can publicize them in the newsletter and other media outlets. You deserve the accolades!

Send items to gillian.irwin@case.edu.