DEVELOPMENTAL THERAPEUTICS
PROGRAM LEADERS
|
Afshin Dowlati, MD Associate Professor, Medicine-Hematology/Oncology axd44@case.edu |
|
Ernest C. Borden, MD Professor, Hematology & Medical Oncology, Cancer Biology bordene@ccf.org |
Program Themes | Program Information | Program Activities | Program Members
Announcements
Limited funds for pilot projects for Case Comprehensive Cancer Center Developmental Therapeutics Program (DTP) Members may be available from the DTP.
Please click here to print the application.
Submit all applications to afshin.dowlati@case.edu
All applications will be reviewed by the Developmental Therapeutic Program Core Committee.
PROGRAM THEMES
- To promote research and discovery of novel anti-cancer agents
- Non-natural nucleosides
- Inhibitors of DNA polymerase
- Inhibitors of ribonucleotide reductase
- Non-natural nucleosides
- To promote disease specific research for new target validation and development of anti-cancer therapies
- Major initiatives
- Melanoma
- Brain tumors
- Other initiatives
- Lung cancer
- Major initiatives
- To pursue mechanism-based early phase human therapeutic studies of anticancer agents linked to biomarker assessments with therapeutic strategies in:
- DNA metabolism and repair
- Cancer angiogenesis
- Cell signaling and apoptotic pathways
PROGRAM INFORMATION
The scientific focus and overall goal of the Developmental Therapeutics Program is to promote the discovery and evaluation of new, mechanism-based therapeutics for the cancer patient from the earliest stages of drug discovery till proof-of-principle therapeutic trials in human subjects. This includes cell-based assays to screen for potential drugs, as well as structure-based approaches to derive at "hit" compounds, which are candidates for further development into "lead" compounds. Program members also are involved in identifying novel pathways for targeting specific malignancies (lung cancer, melanoma, brain tumor initiatives). Finally, investigators lead innovative Phase I and Phase II clinical trials with novel agents, incorporating pharmacokinetic and pharmacodynamic studies to monitor drug effects and to develop relevant biomarkers by integrating correlative laboratory endpoints.
PROGRAM ACTIVITIES
PROGRAM MEMBERS
David J. Adelstein, MD
Professor, Solid Tumor Oncology
adelstd@ccf.org
James M. Anderson, MD, PhD
Professor, Pathology
james.anderson@case.edu
Eric J. Arts, PhD
Professor, Medicine-Infectious Diseases
eja3@case.edu
Bruce J. Averbook, MD
Associate Professor, Surgery
baverbook@metrohealth.org
Joseph Baar, MD, PhD
Associate Professor, Medicine-Hematology/Oncology
joseph.baar@UHhospitals.org
Gene H. Barnett, MD
Professor, Neurological Surgery
barnetg@ccf.org
Elma D. Baron, MD
Associate Professor, Dermatology
edb4@case.edu
Paul M. Barr, MD
Assistant Professor, Medicine-Hematology/Oncology
paul.barr@case.edu
Jerome L. Belinson, MD
Professor, Obstetrics & Gynecology
belinsj@ccf.org
Anthony J. Berdis, PhD
Assistant Professor, Pharmacology
ajb15@case.edu
Joseph A. Bokar, MD, PhD
Assistant Professor, Medicine/Hematology-Oncology
jab5@case.edu
Ernest C. Borden, MD
Professor, Hematology & Medical Oncology, Cancer Biology
bordene@ccf.org
G. Thomas Budd, MD
Professor, Hematology & Medical Oncology
buddg@ccf.org
Clemens Burda, PhD
Associate Professor, Chemistry
cxb77@case.edu
Mellar P. Davis, MD, FCCP
Professor, Hematology & Medical Oncology
davism6@ccf.org
Chris G. Dealwis, PhD
Associate Professor, Pharmacology, Proteomics
chris.dealwis@case.edu
Afshin Dowlati, MD
Associate Professor, Medicine-Hematology/Oncology
axd44@case.edu
Paul J. Elson, ScD
Associate Staff, Quantitative Health Sciences
elsonp@ccf.org
Lois C. Friedman, PhD
Professor, Psychiatry
lois.friedman@UHhospitals.org
Pingfu Fu, PhD
Assistant Professor, Epidemiology & Biostatistics
pxf16@case.edu
Ram N. Ganapathi, PhD
Professor, Hematology & Medical Oncology
ganapar@ccf.org
Stanton L. Gerson, MD
Director, Case Comprehensive Cancer Center
Professor, Medicine-Hematology/Oncology
slg5@case.edu
Harry S. Gill, PhD
Assistant Professor, Physiology & Biophysics
harry.gill@case.edu
Miklos Gratzl, PhD
Associate Professor, Biomedical Engineering
mxg13@case.edu
Charles L. Hoppel, MD
Professor, Clinical Pharmacology
clh5@case.edu
Damir Janigro, PhD
Professor, Neurosurgery
janigrd@ccf.org
Smitha S. Krishnamurthi, MD
Assistant Professor, Medicine-Hematology/Oncology
ssk7@case.edu
Charles A. Kunos, MD, PhD
Assistant Professor, Radiation Oncology
charles.kunos@UHhospitals.org
Vinod Labhasetwar, PhD
Professor, Biomedical Engineering
labhasv@ccf.org
Pierre Lavertu, MD
Professor, Otolaryngology
pierre.lavertu@UHhospitals.org
Rosemary A. Leeming, MD
Assistant Professor, Surgery
rosemary.leeming@UHhospitals.org
Rom S. Leidner, MD
Visiting Instructor, Medicine– Hematology/Oncology
rxl87@case.edu
Nathan A. Levitan, MD
Professor, Medicine-Hematology/Oncology
nxl8@case.edu
Lili Liu, MD, PhD
Associate Professor, Medicine-Hematology/Oncology
lxl32@case.edu
Patrick C. Ma, MD, MSc
Assistant Professor, Medicine-Hematology/Oncology
pcm9@case.edu
Mitchell Machtay, MD
Professor, Radiation Oncology
mitchell.machtay@uhhospitals.org
Charles J. Nock, MD
Assistant Professor, Medicine-Hematology/Oncology
charles.nock@UHhospitals.org
Timothy E. O'Brien, MD
Associate Professor, Medicine-Hematology/Oncology
tobrien@metrohealth.org
Richard A. Padgett, PhD
Associate Professor, Molecular Genetics
padgetr@ccf.org
David M. Peereboom, MD
Associate Professor, Hematology & Medical Oncology
peerebd@ccf.org
Nathan A. Pennell, MD, PhD
Associate Staff, Solid Tumor Oncology
penneln@ccf.org
Peter G. Rose, MD
Professor, Obstetrics & Gynecology
rosep@ccf.org
Panayiotis Savvides, MD, PhD
Assistant Professor, Medicine-Hematology/Oncology
panayiotis.savvides@case.edu
Paula Silverman, MD
Associate Professor, Medicine-Hematology/Oncology
pxs7@case.edu
David W. Stepnick, MD, FACS
Associate Professor, Otolaryngology
david.stepnick@UHhospitals.org
Jean T. Stevenson, MD
Associate Professor, Surgery
jstevenson@metrohealth.org
Gregory P. Tochtrop, PhD
Assistant Professor, Chemistry
gpt6@case.edu
Joan E. Trey, MD
Associate Professor, Medicine-Hematology/Oncology
jet2@case.edu
Michael A. Vogelbaum, MD, PhD
Associate Professor, Neurosurgery
vogelbm@ccf.org
Steven E. Waggoner, MD
Associate Professor, Reproductive Biology
steven.waggoner@UHhospitals.org
David N. Wald, MD, PhD
Instructor, Pathology
dnw@case.edu
Yan Xu, PhD
Professor, Chemistry
yan.xu@case.edu
Yu-Chung Yang, PhD
Professor, Biochemistry
yxy36@case.edu
Taolin Yi, PhD
Associate Professor, Cancer Biology
yit@ccf.org
Kristine M. Zanotti, MD
Assistant Professor, Reproductive Biology
kristine.zanotti@UHhospitals.org