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DEVELOPMENTAL THERAPEUTICS

PROGRAM LEADERS

Dr. Dowlati Afshin Dowlati, MD
Associate Professor, Medicine-Hematology/Oncology
axd44@case.edu
Dr. Borden Ernest C. Borden, MD
Professor, Hematology & Medical Oncology, Cancer Biology
bordene@ccf.org

Program Themes | Program Information | Program Activities | Program Members


Announcements

Limited funds for pilot projects for Case Comprehensive Cancer Center Developmental Therapeutics Program (DTP) Members may be available from the DTP.

Please click here to print the application.

Submit all applications to afshin.dowlati@case.edu

All applications will be reviewed by the Developmental Therapeutic Program Core Committee.


PROGRAM THEMES

  • To promote research and discovery of novel anti-cancer agents
    • Non-natural nucleosides
      • Inhibitors of DNA polymerase
      • Inhibitors of ribonucleotide reductase
  • To promote disease specific research for new target validation and development of anti-cancer therapies
    • Major initiatives
      • Melanoma
      • Brain tumors
    • Other initiatives
      • Lung cancer
  • To pursue mechanism-based early phase human therapeutic studies of anticancer agents linked to biomarker assessments with therapeutic strategies in:
    • DNA metabolism and repair
    • Cancer angiogenesis
    • Cell signaling and apoptotic pathways

PROGRAM INFORMATION

The scientific focus and overall goal of the Developmental Therapeutics Program is to promote the discovery and evaluation of new, mechanism-based therapeutics for the cancer patient from the earliest stages of drug discovery till proof-of-principle therapeutic trials in human subjects. This includes cell-based assays to screen for potential drugs, as well as structure-based approaches to derive at "hit" compounds, which are candidates for further development into "lead" compounds. Program members also are involved in identifying novel pathways for targeting specific malignancies (lung cancer, melanoma, brain tumor initiatives). Finally, investigators lead innovative Phase I and Phase II clinical trials with novel agents, incorporating pharmacokinetic and pharmacodynamic studies to monitor drug effects and to develop relevant biomarkers by integrating correlative laboratory endpoints.


PROGRAM ACTIVITIES activities calendar



PROGRAM MEMBERS

David J. Adelstein, MD
Professor, Solid Tumor Oncology
adelstd@ccf.org

James M. Anderson, MD, PhD
Professor, Pathology
james.anderson@case.edu

Eric J. Arts, PhD
Professor, Medicine-Infectious Diseases
eja3@case.edu

Bruce J. Averbook, MD
Associate Professor, Surgery
baverbook@metrohealth.org

Joseph Baar, MD, PhD
Associate Professor, Medicine-Hematology/Oncology
joseph.baar@UHhospitals.org

Gene H. Barnett, MD
Professor, Neurological Surgery
barnetg@ccf.org

Elma D. Baron, MD
Associate Professor, Dermatology
edb4@case.edu

Paul M. Barr, MD
Assistant Professor, Medicine-Hematology/Oncology
paul.barr@case.edu

Jerome L. Belinson, MD
Professor, Obstetrics & Gynecology
belinsj@ccf.org

Anthony J. Berdis, PhD
Assistant Professor, Pharmacology
ajb15@case.edu

Joseph A. Bokar, MD, PhD
Assistant Professor, Medicine/Hematology-Oncology
jab5@case.edu

Ernest C. Borden, MD
Professor, Hematology & Medical Oncology, Cancer Biology
bordene@ccf.org

G. Thomas Budd, MD
Professor, Hematology & Medical Oncology
buddg@ccf.org

Clemens Burda, PhD
Associate Professor, Chemistry
cxb77@case.edu

Mellar P. Davis, MD, FCCP
Professor, Hematology & Medical Oncology
davism6@ccf.org

Chris G. Dealwis, PhD
Associate Professor, Pharmacology, Proteomics
chris.dealwis@case.edu

Afshin Dowlati, MD
Associate Professor, Medicine-Hematology/Oncology
axd44@case.edu

Paul J. Elson, ScD
Associate Staff, Quantitative Health Sciences
elsonp@ccf.org

Lois C. Friedman, PhD
Professor, Psychiatry
lois.friedman@UHhospitals.org

Pingfu Fu, PhD
Assistant Professor, Epidemiology & Biostatistics
pxf16@case.edu

Ram N. Ganapathi, PhD
Professor, Hematology & Medical Oncology
ganapar@ccf.org

Stanton L. Gerson, MD
Director, Case Comprehensive Cancer Center
Professor, Medicine-Hematology/Oncology
slg5@case.edu

Harry S. Gill, PhD
Assistant Professor, Physiology & Biophysics
harry.gill@case.edu

Miklos Gratzl, PhD
Associate Professor, Biomedical Engineering
mxg13@case.edu

Charles L. Hoppel, MD
Professor, Clinical Pharmacology
clh5@case.edu

Damir Janigro, PhD
Professor, Neurosurgery
janigrd@ccf.org

Smitha S. Krishnamurthi, MD
Assistant Professor, Medicine-Hematology/Oncology
ssk7@case.edu

Charles A. Kunos, MD, PhD
Assistant Professor, Radiation Oncology
charles.kunos@UHhospitals.org

Vinod Labhasetwar, PhD
Professor, Biomedical Engineering
labhasv@ccf.org

Pierre Lavertu, MD
Professor, Otolaryngology
pierre.lavertu@UHhospitals.org

Rosemary A. Leeming, MD
Assistant Professor, Surgery
rosemary.leeming@UHhospitals.org

Rom S. Leidner, MD
Visiting Instructor, Medicine– Hematology/Oncology
rxl87@case.edu

Nathan A. Levitan, MD
Professor, Medicine-Hematology/Oncology
nxl8@case.edu

Lili Liu, MD, PhD
Associate Professor, Medicine-Hematology/Oncology
lxl32@case.edu

Patrick C. Ma, MD, MSc
Assistant Professor, Medicine-Hematology/Oncology
pcm9@case.edu

Mitchell Machtay, MD
Professor, Radiation Oncology
mitchell.machtay@uhhospitals.org

Charles J. Nock, MD
Assistant Professor, Medicine-Hematology/Oncology
charles.nock@UHhospitals.org

Timothy E. O'Brien, MD
Associate Professor, Medicine-Hematology/Oncology
tobrien@metrohealth.org

Richard A. Padgett, PhD
Associate Professor, Molecular Genetics
padgetr@ccf.org

David M. Peereboom, MD
Associate Professor, Hematology & Medical Oncology
peerebd@ccf.org

Nathan A. Pennell, MD, PhD
Associate Staff, Solid Tumor Oncology
penneln@ccf.org

Peter G. Rose, MD
Professor, Obstetrics & Gynecology
rosep@ccf.org

Panayiotis Savvides, MD, PhD
Assistant Professor, Medicine-Hematology/Oncology
panayiotis.savvides@case.edu

Paula Silverman, MD
Associate Professor, Medicine-Hematology/Oncology
pxs7@case.edu

David W. Stepnick, MD, FACS
Associate Professor, Otolaryngology
david.stepnick@UHhospitals.org

Jean T. Stevenson, MD
Associate Professor, Surgery
jstevenson@metrohealth.org

Gregory P. Tochtrop, PhD
Assistant Professor, Chemistry
gpt6@case.edu

Joan E. Trey, MD
Associate Professor, Medicine-Hematology/Oncology
jet2@case.edu

Michael A. Vogelbaum, MD, PhD
Associate Professor, Neurosurgery
vogelbm@ccf.org

Steven E. Waggoner, MD
Associate Professor, Reproductive Biology
steven.waggoner@UHhospitals.org

David N. Wald, MD, PhD
Instructor, Pathology
dnw@case.edu

Yan Xu, PhD
Professor, Chemistry
yan.xu@case.edu

Yu-Chung Yang, PhD
Professor, Biochemistry
yxy36@case.edu

Taolin Yi, PhD
Associate Professor, Cancer Biology
yit@ccf.org

Kristine M. Zanotti, MD
Assistant Professor, Reproductive Biology
kristine.zanotti@UHhospitals.org

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