DEVELOPMENTAL THERAPEUTICS
PROGRAM LEADERS
|
Afshin Dowlati, MD Associate Professor, Medicine-Hematology/Oncology axd44@case.edu |
|
Jeffrey L. Duerk, PhD Professor, Radiology, Biomedical Engineering duerk@case.edu |
Program Themes | Program Information | Program Activities | Program Members
Announcements
Limited funds for pilot projects for Case Comprehensive Cancer Center Developmental Therapeutics Program (DTP) Members may be available from the DTP.
Please click here to print the application.
Submit all applications to afshin.dowlati@case.edu
All applications will be reviewed by the Developmental Therapeutic Program Core Committee.
PROGRAM THEMES
-
To pursue mechanism-based novel anticancer drug development linked to
biomarker assessments led by Dr. Afshin Dowlati with therapeutic strategies in:
- DNA metabolism and repair
- Cancer angiogenesis
- Cell signaling and apoptotic pathways
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To develop and integrate non-invasive/minimally invasive cancer imaging
strategies led by Dr. Jeffrey Duerk linked to our drug development efforts
to monitor drug effects and image drug distribution with several leading
imaging platforms. Projects include:
- 11C-labelled topotecan imaging - linked to therapeutic strategy in DNA metabolism and repair
- DCE-MRI for monitoring tumor blood flow and 111Indium-labelled VEGF Trap pilot project-linked to therapeutic strategy in cancer angiogenesis
- Development of multi-modal imaging techniques to monitor response to Pc 4-photodynamic therapy (Pc 4-PDT) - linked to strategy in apoptotic pathways
- To develop non-invasive/minimally invasive cancer imaging strategies led by Dr. Duerk to detect cancer and to develop image-based methods for delivering and assessing novel image-guided therapies.
PROGRAM INFORMATION
The scientific focus and overall goal of the Developmental Therapeutics Program is to promote the discovery and evaluation of new, mechanism-based therapeutics for the cancer patient. Program investigators lead innovative Phase I and Phase II clinical trials with novel agents, incorporating pharmacokinetic and pharmacodynamic studies to monitor drug effects, and to develop relevant biomarkers by integrating correlative laboratory endpoints and capitalizing on cancer imaging technologies.
PROGRAM ACTIVITIES
PROGRAM MEMBERS
David J. Adelstein, MD
Professor, Solid Tumor Oncology
adelstd@ccf.org
James M. Anderson, MD, PhD
Professor, Pathology
james.anderson@case.edu
Eric J. Arts, PhD
Associate Professor, Medicine-Infectious Diseases
eja3@case.edu
Bruce J. Averbook, MD
Associate Professor, Surgery
baverbook@metrohealth.org
Joseph Baar, MD, PhD
Associate Professor, Medicine-Hematology/Oncology
joseph.baar@UHhospitals.org
Gene H. Barnett, MD
Professor, Neurological Surgery
barnetg@ccf.org
Paul M. Barr, MD
Assistant Professor, Medicine-Hematology/Oncology
paul.barr@case.edu
James P. Basilion, PhD
Associate Professor, Radiology, Biomedical Engineering
james.basilion@case.edu
Jerome L. Belinson, MD
Professor, Obstetrics & Gynecology
belinsj@ccf.org
Joseph A. Bokar, MD, PhD
Assistant Professor, Medicine/Hematology-Oncology
jab5@case.edu
Ernest C. Borden, MD
Professor, Hematology & Medical Oncology, Cancer Biology
bordene@ccf.org
Joanna M. Brell, MD
Assistant Professor, Medicine-Hematology/Oncology
jmb46@case.edu
Ann-Marie Broome, PhD
Assistant Professor, Biomedical Engineering
axb110@case.edu
G. Thomas Budd, MD
Professor, Hematology & Medical Oncology
buddg@ccf.org
Mellar P. Davis, MD, FCCP
Staff, Hematology & Medical Oncology
davism6@ccf.org
Chris G. Dealwis, PhD
Associate Professor, Pharmacology, Proteomics
chris.dealwis@case.edu
David Dean, PhD
Associate Professor, Neurological Surgery
dxd35@case.edu
Afshin Dowlati, MD
Associate Professor, Medicine-Hematology/Oncology
axd44@case.edu
Jeffrey L. Duerk, PhD
Professor, Radiology, Biomedical Engineering
duerk@case.edu
Paul J. Elson, ScD
Associate Staff, Quantitative Health Sciences
elsonp@ccf.org
Agata A. Exner, PhD
Assistant Professor, Radiology
exner@uhrad.com
Maryann Fitzmaurice, MD, PhD
Associate Professor, Pathology
mxf39@case.edu
Christopher A. Flask, PhD
Assistant Professor, Radiology
flask@uhrad.com
Lois C. Friedman, PhD
Professor, Psychiatry
lois.friedman@UHhospitals.org
Pingfu Fu, PhD
Assistant Professor, Epidemiology & Biostatistics
pxf16@case.edu
Koh Fujinaga, PhD
Assistant Professor, Medicine-Infectious Diseases
kxf32@case.edu
Ram N. Ganapathi, PhD
Professor, Hematology & Medical Oncology
ganapar@ccf.org
Miklos Gratzl, PhD
Associate Professor, Biomedical Engineering
mxg13@case.edu
John R. Haaga, MD
Professor, Radiology
jrh7@case.edu
Balazs Halmos, MD
Assistant Professor, Medicine-Hematology/Oncology
balazs.halmos@case.edu
Charles L. Hoppel, MD
Professor, Clinical Pharmacology
clh5@case.edu
Damir Janigro, PhD
Professor, Neurosurgery
janigrd@ccf.org
Smitha S. Krishnamurthi, MD
Assistant Professor, Medicine-Hematology/Oncology
ssk7@case.edu
Charles A. Kunos, MD, PhD
Assistant Professor, Radiation Oncology
charles.kunos@UHhospitals.org
Vinod Labhasetwar, PhD
Professor, Biomedical Engineering
labhasv@ccf.org
Pierre Lavertu, MD
Professor, Otolaryngology
pierre.lavertu@UHhospitals.org
Zhenghong Lee, PhD
Associate Professor, Radiology, Biomedical Engineering
zxl11@case.edu
Rosemary A. Leeming, MD
Assistant Professor, Surgery
rosemary.leeming@UHhospitals.org
Nathan A. Levitan, MD
Professor, Medicine-Hematology/Oncology
nxl8@case.edu
Patrick C. Ma, MD, MSc
Assistant Professor, Medicine-Hematology/Oncology
pcm9@case.edu
Robert J. Maciunas, MD
Professor, Neurosurgery, Radiation Oncology
rjm31@case.edu
Tarek M. Mekhail, MD
Assistant Professor, Hematology & Medical Oncology
mekhait@ccf.org
Raymond F. Muzic, Jr., PhD
Associate Professor, Radiology
raymond.muzic@case.edu
Dean A. Nakamoto, MD
Assistant Professor, Radiology
nakamoto@uhrad.com
Charles J. Nock, MD
Assistant Professor, Medicine-Hematology/Oncology
charles.nock@UHhospitals.org
Sherif G. Nour, MD
Assistant Professor, Radiology
nour@uhrad.com
Louis J. Novak, MD
Assistant Professor, Radiation Oncology
dr1192@lhs.net
Timothy E. O'Brien, MD
Associate Professor, Medicine-Hematology/Oncology
tobrien@metrohealth.org
James K. O'Donnell, MD
Associate Professor, Radiology
odonnell@uhrad.com
Richard A. Padgett, PhD
Associate Professor, Molecular Genetics
padgetr@ccf.org
David M. Peereboom, MD
Associate Professor, Hematology & Medical Oncology
peerebd@ccf.org
Andrew M. Rollins, PhD
Associate Professor, Biomedical Engineering
amr9@case.edu
Peter G. Rose, MD
Professor, Obstetrics & Gynecology
rosep@ccf.org
Gerald M. Saidel, PhD
Professor, Biomedical Engineering
gms3@case.edu
Panayiotis Savvides, MD, PhD
Assistant Professor, Medicine-Hematology/Oncology
panayiotis.savvides@case.edu
Anirban Sen Gupta, PhD
Assistant Professor, Biomedical Engineering
anirban.sengupta@case.edu
Paula Silverman, MD
Associate Professor, Medicine-Hematology/Oncology
pxs7@case.edu
Andrew E. Sloan, MD
Associate Professor, Neurological Surgery
andrew.sloan@UHhospitals.org
David W. Stepnick, MD, FACS
Associate Professor, Otolaryngology
david.stepnick@UHhospitals.org
Jean T. Stevenson, MD
Associate Professor, Surgery
jstevenson@metrohealth.org
Jeffrey L. Sunshine, MD, PhD
Associate Professor, Radiology
sunshine@uhrad.com
Joan E. Trey, MD
Associate Professor, Medicine-Hematology/Oncology
jet2@case.edu
Michael A. Vogelbaum, MD, PhD
Associate Professor, Neurosurgery
vogelbm@ccf.org
Vivian E. von Gruenigen, MD
Associate Professor, Reproductive Biology
vivian.vongruenigen@UHhospitals.org
Horst A. von Recum, PhD
Assistant Professor, Biomedical Engineering
horst.vonrecum@case.edu
Steven E. Waggoner, MD
Associate Professor, Reproductive Biology
steven.waggoner@UHhospitals.org
David N. Wald, MD, PhD
Instructor, Pathology
dnw@case.edu
Yanming Wang, PhD
Associate Professor, Radiology
yanming.wang@case.edu
David L. Wilson, PhD
Professor, Biomedical Engineering
dlw@case.edu
Yan Xu, PhD
Professor, Chemistry
yan.xu@case.edu
Taolin Yi, PhD
Associate Professor, Cancer Biology
yit@ccf.org
Kristine M. Zanotti, MD
Assistant Professor, Reproductive Biology
kristine.zanotti@UHhospitals.org