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FUNDING AGENCIES:

CELL PROLIFERATION AND CELL DEATH

PROGRAM LEADER

Clark W. Distelhorst, MD
Professor, Medicine-Hematology/Oncology, Pharmacology
cwd@case.edu

Program Themes | Program Information | Program Members | Focus Groups


PROGRAM THEMES

  • Identification of gene expression changes that mediate hormonal effects on cancer cells
  • Investigation of signaling pathways that regulate cell proliferation and cell death

PROGRAM INFORMATION

The central theme of this Program is to understand the signaling pathways that regulate cell proliferation and cell death, and the hormonal regulation of these processes. Aberrancies of cell growth and cell death are fundamental problems that contribute to the pathogenesis of virtually all forms of cancer. Also, many forms of cancer therapy have the intent of inhibiting cell proliferation or inducing cell death. Hormonal regulation of both cell proliferation and cell death are of direct relevance to the pathogenesis of cancer, the prevention of cancer and the treatment of cancer. Also, glucocorticosteroid hormones are among the most effective agents employed in the treatment of a wide variety of lymphoid malignancies and epidemiological studies have provided strong evidence that estrogens provide a protective role against colon cancer. The efficacy of glucocorticoids in treating lymphoid malignancies stems from their ability to induce apoptosis in immature lymphocytes. Two specific hormone-responsive malignancies are topics of basic investigation with translational potential in this program: breast cancer and lymphoid malignancies. Research in this program is particularly relevant to cancers in which cell proliferation and cell death decisions are regulated by members of the nuclear receptor family. Although hormone-responsive malignancies are the central cancer-related feature of this program, our work is also contributing to an understanding of the regulation of cell proliferation and cell death relevant to other types of cancer.

PROGRAM MEMBERS

Clemencia Colmenares, PhD
Staff, Cancer Biology
colmenc@ccf.org

L.R. Devireddy, PhD
Assistant Professor, Pathology
laxminarayana.devireddy@case.edu

Clark W. Distelhorst, MD
Professor, Medicine-Hematology/Oncology, Pharmacology
cwd@case.edu

George I. Gorodeski, MD, PhD
Professor, Reproductive Biology
gig@case.edu

Subrata Haldar, PhD
Associate Professor, Pharmacology
shaldar@metrohealth.org

Janet A. Houghton, PhD
Chair, Cancer Biology
houghtj@ccf.org

Philip H. Howe, PhD
Professor, Cancer Biology, Physiology & Biophysics
howep@ccf.org

James W. Jacobberger, PhD
Professor, General Medical Sciences (Oncology)
jwj@case.edu

David R. Kaplan, MD, PhD
Professor, Pathology
drk5@case.edu

Ruth A. Keri, PhD
Associate Professor, Pharmacology
rak5@case.edu

John J. Letterio, MD
Professor, Pediatric Hematology/Oncology
john.letterio@UHhospitals.org

Alan D. Levine, PhD
Professor, Medicine-Gastroenterology
adl4@case.edu

Paul N. MacDonald, PhD
Associate Professor, Pharmacology
pnm2@case.edu

Danny Manor, PhD
Associate Professor, Nutrition
danny.manor@case.edu

John J. Mieyal, PhD
Professor, Pharmacology
jjm5@case.edu

Monica M. Montano, PhD
Associate Professor, Pharmacology
mxm126@case.edu

Noa Noy, PhD
Professor, Pharmacology
noa.noy@case.edu

Catherine E. Patterson, PhD
Assistant Professor, Molecular Biology & Microbiology
cep8@case.edu

Dennis W. Stacey, PhD
Professor, Molecular Genetics
staceyd@ccf.org

Edward Stavnezer, PhD
Professor, Biochemistry
exs44@case.edu

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