Program Leaders

The central theme of this Program is to understand the signaling pathways that regulate cell proliferation and cell death, and the hormonal regulation of these processes. Aberrancies of cell growth and cell death are fundamental problems that contribute to the pathogenesis of virtually all forms of cancer. Also, many forms of cancer therapy have the intent of inhibiting cell proliferation or inducing cell death. Hormonal regulation of both cell proliferation and cell death are of direct relevance to the pathogenesis of cancer, the prevention of cancer and the treatment of cancer. Also, glucocorticosteroid hormones are among the most effective agents employed in the treatment of a wide variety of lymphoid malignancies and epidemiological studies have provided strong evidence that estrogens provide a protective role against colon cancer. The efficacy of glucocorticoids in treating lymphoid malignancies stems from their ability to induce apoptosis in immature lymphocytes. Two specific hormone-responsive malignancies are topics of basic investigation with translational potential in this program: breast cancer and lymphoid malignancies. Research in this program is particularly relevant to cancers in which cell proliferation and cell death decisions are regulated by members of the nuclear receptor family. Although hormone-responsive malignancies are the central cancer-related feature of this program, our work is also contributing to an understanding of the regulation of cell proliferation and cell death relevant to other types of cancer.

Program Activities

Program Members

Alexandru Almasan, PhD
Professor, Cancer Biology, Radiation Oncology
almasaa@ccf.org

Shideng Bao, PhD
Associate Professor, Stem Cell Biology and Regenerative Medicine
baos@ccf.org

Barbara Bedogni, PhD
Assistant Professor, Biochemistry
bxb278@case.edu

G. Valentin Börner, PhD
Associate Professor, Biology
g.boerner@csuohio.edu

Paolo Caimi, MD
Assistant Professor, Medicine-Hematology/Oncology
pxc125@case

L.R. Devireddy, PhD
Assistant Professor, Pathology
laxminarayana.devireddy@case.edu

Clark W. Distelhorst, MD
Professor, Medicine-Hematology/Oncology, Pharmacology
cwd@case.edu

Neetu Gupta, PhD
Assistant Professor, Immunology
guptan@ccf.org

Subrata Haldar, PhD
Associate Professor, Pharmacology
shaldar@metrohealth.org

Brian T. Hill, MD, PhD
Assistant Professor, Hematologic Oncology and Blood Disorders
hillb2@ccf.org

Janet A. Houghton, PhD
Professor, Cancer Biology
houghtj@ccf.org

Ge Jin, PhD
Assistant Professor, Biological Sciences
ge.jin@case.edu

Malcolm E. Kenney, PhD
Professor, Chemistry
mek9@case.edu

Minh Lam, PhD
Assistant Professor, Dermatology
minh.lam@case.edu

John J. Letterio, MD
Professor, Pediatric Hematology/Oncology
john.letterio@UHhospitals.org

Bibo Li, PhD
Associate Professor, Biological, Geological, and Environmental Sciences
b.li37@csuohio.edu

Daniel J. Lindner, MD, PhD
Assistant Professor, Cancer Biology
lindned@ccf.org

Guangbin Luo, PhD
Associate Professor, Genetics
gxl35@case.edu

Roger M. Macklis, MD
Professor, Radiation Oncology
macklir@ccf.org

Shigemi Matsuyama, PhD
Associate Professor, Medicine-Hematology/Oncology
sxm193@case.edu

Edward V. Maytin, MD, PhD
Assistant Professor, Dermatology, Biomedical Engineering
maytine@ccf.org

John J. Mieyal, PhD
Professor, Pharmacology
jjm5@case.edu

Nancy L. Oleinick, PhD
Professor, Radiation Oncology
nlo@case.edu

Kurt W. Runge, PhD
Associate Professor, Molecular Genetics
rungek@ccf.org

Neena Singh, MD, PhD
Professor, Pathology
neena.singh@case.edu

Mitchell R. Smith, MD, PhD
Professor, Solid Tumor Oncology
smithm14@ccf.org

Matthew K. Summers, PhD
Assistant Staff, Cancer Biology
summerm@ccf.org

Man-Sun Sy, PhD
Professor, Pathology
mxs92@case.edu

Hisashi Tanaka, MD, PhD
Assistant Professor, Molecular Genetics
tanakah@ccf.org

Derek J. Taylor, PhD
Assistant Professor, Pharmacology
derek.taylor@case.edu

Saba Valadkhan, MD, PhD
Assistant Professor, RNA Molecular Biology
saba.valadkhan@case.edu

Scott Welford, PhD
Assistant Professor, Radiation Oncology
scott.welford@case.edu

Vivien C. Yee, PhD
Associate Professor, Biochemistry
vcy2@case.edu

Junran Zhang, MD, PhD
Assistant Professor, Radiation Oncology
junran.zhang@case.edu

Youwei Zhang, PhD
Assistant Professor, Pharmacology
yxz169@case.edu