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Case Comprehensive Cancer Center

Adolescent and Young Adult Cancer

Adolescent and Young Adult Cancer

Angie Fowler Adolescent and Young Adult (AYA) Cancer Research Initiative

In 2014, Chuck and Char Fowler made a philanthropic pledge of $6.7 million to the Case Comprehensive Cancer Center to establish and develop the Angie Fowler Adolescent & Young Adult (AYA) Research Program to augment and complement the Angie Fowler Adolescent & Young Adult Cancer Institute at University Hospitals (UH) Rainbow Babies & Children's Hospital. This pledge injected critical support for research into cancers affecting adolescents and young adults, and will help to fund recruitment, pilot studies and transdisciplinary, multi-investigator research at a time when there is little NIH support for this sector.

The initiative, led by Drs. John Letterio and Stan Gerson, promotes basic understanding of the biology of the metastatic process and of therapy resistance in cancers that occur in this age group, and it also leverages expertise in imaging, drug development and other cross-institutional facets of the Case Comprehensive Cancer Center in relation to AYA cancers. An important program goal is to increase the opportunities for participation in the clinical trials process, as currently less than two percent of patients between the ages 15-30 are actively involved in clinical trials.

The support of the Fowlers and prioritization by the Case Comprehensive Cancer Center of studies focused on cancers occurring in the 15-to-30 age range marks the first creation of an AYA-dedicated center within a NCI-designated Comprehensive Cancer Center. With cross-center collaboration, our hope is to make an impact on the prognosis for distinct cancers that affect the AYA population, such as Ewing sarcoma and osteosarcoma. These cancers, while rare in young individuals, are often highly metastatic with few or no curative treatments in advanced stages. 

Adolescent and Young Adult (AYA) Cancer Research Awards

These one-year awards, made possible through the Fowler family's generous support of AYA cancer research at the Case Comprehensive Cancer Center, are granted to members of the AYA Cancer Research Initiative. The objective of these awards is to broaden and deepen research focus on AYA cancers and to engage members across the Center in this important area. Click here to learn more

Members

Barbara Bedogni, PhD
Assistant Professor, Biochemistry
bxb278@case.edu

Susann M. Brady-Kalnay, PhD
Professor, Molecular Biology & Microbiology
smb4@case.edu

Paolo Caimi, MD
Assistant Professor, Medicine- Hematology and Oncology 
paolo.caimi@case.edu

Peter de Blank, MD
Assistant Professor, Pediatric Hematology and Oncology
peter.deBlank@UHhospitals.org

Marcos de Lima, MD
Professor, Medicine- Hematology and Oncology
marcos.delima@UHhospitals.org

Mark A. Griswold, PhD
Professor, Radiology
mag46@case.edu

Alex Y.C. Huang, MD, PhD
Associate Professor, Pediatric Hematology and Oncology
alex.y.huang@case.edu

Efstathios Karathanasis, PhD
Assistant Professor, Biomedical Engineering and Radiology
stathis@case.edu

John J. Letterio, MD
Professor, Pediatric Hematology and Oncology 
john.letterio@UHhospitals.org

Yousif Matloub, MD
Professor, Pediatric Hematology and Oncology
yousif.matloub@UHhospitals.org

Robin E. Norris, MD, MS, MPH
Assistant Professor, Pediatric Hematology and Oncology
robin.norris@UHhospitals.org

Agne Petrosiute, MD
Assistant Professor, Pediatric Hematology and Oncology
axp125@case.edu

David N. Wald, MD, PhD
Assistant Professor, Clinical Pathology
dnw@case.edu

Lan Zhou, MD, PhD
Associate Professor, Pathology
lan.zhou@case.edu