CANCER PHARMACOLOGY CORE FACILITY
Director: Yan Xu, PhD
Professor, Chemistry
yan.xu@case.edu
Services
The Cancer Pharmacology Core Facility provides accessible, timely and comprehensive analytical services to early phase clinical studies and basic cancer research. It supports the translational research objectives of the Developmental Therapeutics Program and the interactive multidisciplinary and multi-coordinated Laboratory Correlates Conference.
The core services include the following:
- Development of CTEP letters of intent (LOI) concepts for early phase studies;
- Pharmacokinetic expertise for investigator-initiated early phase studies with planned PK analyses;
- Sample procurement schedules for pharmacokinetic assays given anticipated or known PK profiles of investigational agents;
- Design and development of analytical methods;
- Adoption and validation of established analytical procedures;
- Quantitative measurement of drugs, metabolites, and other small molecules;
- Pharmacokinetic data analysis;
- Collaborative writing;
- Training
Resources
- An Applied Biosystems API 3200 triple quadrupole tandem mass spectrometer coupled with a Shimadzu LC-20 series HPLC system with SPD-M20A photodiode array/RF-10AxL fluorescence detectors and SIL-20AC refrigerated autosampler.
- A Shimadzu QP8000 liquid chromatograph-mass spectrometer system equipped with both ESI and APCI probes, an autosampler, and a degasser.
- An Aligent 1100 liquid chromatograph equipped with binary pump, vacuum degasser, refrigerated autosampler, thermostatted column compartment, and multi-wavelength UV detector.
- A Varian Saturn 2200 ion trap mass spectrometer coupled with a CP-3800 gas chromatograph and a CP-8400 autosampler.
- Equipments for biological sample preparation and storage.
- Computers and data storage devices.
- Software for pharmacokinetic and pharmacodynamic analyses.
Fees
The Facility activities are funded by inclusion in grants and contracts of investigators who use the Facility services. In view of wide variety of drugs and lead compounds, and diversified analytical challenges imposed by experimental protocols, specific costs for individual assays can be calculated upon request, which are based on the estimated staff time, consumable supplies, and prorated instrument maintenance costs.
Contact for Information
| Location: | 11001 Cedar Avenue, Suite 200 Cleveland, Ohio 44106 |
| Director: | Yan Xu, PhD |
| Phone: | 440/382-4375 |
| Email: | yan.xu@case.edu |