Proteomics Core Facility

Dr. Chance Proteomics Core

Director: Mark R. Chance, PhD
Professor, Physiology & Biophysics
mark.chance@case.edu

Assistant Director: Janna Kiselar, PhD
Instructor, Center for Proteomics and Bioinformatics
janna.kiselar@case.edu

Co-Director: Belinda B. Willard, PhD
Staff, Cell Biology
willarb@ccf.org

Remember to acknowledge the valuable services provided by Cancer Center Core Facilities in your research papers and publications:
"This research was supported by the Proteomics Core Facility of the Case Comprehensive Cancer Center (P30 CA43703)."


Services

The overall goal of the Proteomics Core Facility is to make advanced mass spectrometry instruments, expertise, and methods for proteome analysis available to all investigators.

Services include the following:

  • Protein Identification
  • Characterization of post-translational modifications
  • Quantitation of protein expression
    • Quantitative Top-Down Proteomics using 2-D gels
    • Quantitative Bottom-Up Proteomics using LC-MS
    • Experimental Design for Quantitative Proteomics
    • Data analysis
  • Bioinformatics analysis
  • Training
  • Independent use

Resources

Case Western Reserve University facility:

  • Thermo-Finnigan Fourier Transform LTQ mass spectrometer
  • GE/Amersham 2-D gel DIGE system
  • Two Applied Biosystems Q-star mass spectrometers
  • Thermo-Finnigan DECA XP-Plus and LTQ instruments
  • Beckman Biomek FX robotic liquid handling systems
  • prOTOF 2000 MALDI Mass Spectrometer

Lerner Research Institute facility:

  • Three capillary column HPLC-electrospray ionization-tandem mass spectrometry systems
  • One MALDI-TOF system (TofSpec 2E)
  • ThermoFinnigan LCQ-deca
  • ThermoFinnigan LTQ
  • Micromass Q-ToFmicro

Further Information

Case Western Reserve University
Center for Proteomics and Bioinformatics
http://proteomics.case.edu/

Cleveland Clinic Lerner Research Institute
Proteomics Laboratory
http://www.lerner.ccf.org/services/mass_spec/


Contact for Information

CWRU FACILITY:
  
LRI FACILITY:
Location: Case BRB 9th floor Location: LRI Room NN1-25
Director: Mark R. Chance, PhD Co-Director: Belinda B. Willard, PhD
Phone: 216.368.4406 Phone: 216.444.7170
E-mail: mark.chance@case.edu E-mail: willarb@ccf.org
General Contact: Janna Kiselar, PhD
Assistant Director
Phone: 216.368.1490  
E-mail: proteomics@case.edu